Price: €7.10
For the treatment and prevention of infections with nematodes and gastrointestinal tract infections and also for the prevention of heartworm disease
Content of the active substance and excipients:
Active substances in one tablet:
Pyrantel pamoate 150 mg
Praziquantel 50 mg
Ivermectin 0.06 mg

Types of animals for which the VMP is intended:
Dogs and cats.
Therapeutic indications:
For the treatment and prevention of invasions with nematodes and cetoides of the gastrointestinal tract and also for the prevention of heartworm disease.
Dosage and route of administration:
In the case of cephalosporin and nematode infections of the gastrointestinal tract, Dironet tablets for healing and safety purposes should be administered individually, orally, once in the morning meal with a small amount of food or forced, directly to the bottom of the tongue, using a dose dispenser of 1 tablet per 10 kg body weight.
For precautionary purposes, it should be given every three months and before each vaccination.
For reduction of circulating microfilaments in animals infected with Dirofilaria immitis and Dirofilaria repens, the product is administered once, once a month.
In order to protect against heartworm disease in areas with a high risk of disease, Dironet tablets are given the spring-summer-autumn period: once before the mosquito season (March-April), then monthly from April to October and last one month after the end of the mosquito season (October-November).
No special diet and laxatives are required.

Withdrawal period:
Not applicable.

Pharmacological features:
The combination of active substances included in the veterinary medicinal product provides a broad anthelmintic effect of all phases of parasites in dogs and cats including Toxocara canis, Toxocara cati, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Trichuris vulpis, Echinococcus granulosus, Echinococcus multilocularis , Diphyllobothrium latum, Dipylidium caninum, Multiceps multiceps, Taenia spp. and also the larval stage of development (microfilament) of Dirofilaria immitis and Dirofilaria repens.
The mechanism of action of pyrantel pamoate consists in blocking neuromuscular impulses, disrupting the permeability of cell membranes, and suppressing cholinesterase, leading to paralysis and parasite death. The maximum pyranol pamoate concentration in blood plasma is set at 2 to 4 hours after administration of the product. Pyrantel pamoate is separated from urine and feces from the body of the animal within 24 hours.
The mechanism of action of praziquantel consists in disrupting glucose transport and microtubule function of the cethodes, inhibiting fumarate reductase activity and ATP synthesis, increasing the permeability of cell membranes and disturbing muscle innervation. Praziquantel is rapidly absorbed from the gastrointestinal tract, its maximal plasma concentration is reached for 30 to 60 minutes. Praziquantel is excreted mainly via urine up to 24 hours.
The mechanism of action of ivermectin lies in its effect on the flow of chloride ions through the membranes of parasitic nerve and muscle cells. The target site of action is glutamate-sensitive nerve channels as well as gamma-aminobutyric acid receptors. The change in chloride ion flow disturbs the transmission of nerve impulses, leading to paralysis and parasite death. The maximum blood plasma ivermectin concentration is reported 9 hours after administration of the product. Ivermectin is excreted from the body through bile, faeces and in part through urine.

Contraindications, warnings, etc:
Do not use in case of hypersensitivity to the active substances or to any of the excipients. Do not use in dogs and cats less than 3 weeks of age. Do not use in productive animals.
Adverse reactions
Not known.
In the event of increased sensitivity to the product and allergic reactions, treatment should be discontinued and the animal should be treated with antihistamines and symptomatic therapy. If you notice any serious effects or other effects due to the use of this VMP that are not listed in this leaflet, please inform your veterinary surgeon immediately.
Special precautions for use:
Dogs of betel, car and shelf breeds have a high sensitivity to macrocyclic lactones, therefore the veterinary medicinal product should be used in these breeds under the direct supervision of the attending vet.
You do not need to follow a special diet when using the product.
Special warnings for each species for which the VMP is intended:
The recommended treatment period should be avoided because this may reduce its effectiveness.
Special precautions to be taken by the person administering the veterinary medicinal product to animals:
When working with Dironet tablets, the basic rules must be observed
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